Gene therapy, the experimental strategy that requires the use of genes to prevent and cure diseases is a fairly new technique, yet it is one which has shown steady advancements. The journal article “Gene therapy clinical trials worldwide to 2012—An update†sets out to present analysis and summaries of clinical trials that have been performed worldwide. Authors Samantha L. Ginn, Ian E. Alexander, Michael Edelstein, Mohammad R. Abedi and Joanne Wixon dive into some of the 1843 gene therapy trials performed in 31 countries. Analyzing geographical distribution of trials, searching for indications of mishaps in trials, speaking on diseases which have been tested in trials and a general introduction to gene therapy are some of the points within the article. The new paradigm gene therapy, is one that houses extraordinary potential dating back to its first successful debut in the year 2000. In its debut gene therapy targeted X-linked severe immunodeficiency (SCID-X1). This disease is usually found in early infancy and can be characterized by reoccurring infections.